Quelle:
Fachblatt
The Lancet
Jugendliche
die nach ihrer Geburt gestillt wurden haben eine um 14% niedrigere
LDL/HDL-Cholesterin-Rate ("böses Cholesterin" im
Vergleich zum "guten Cholesterin") als ihre Altersgenossen,
die mit industriell gefertigter Babynahrung ernährt wurden.
Dadurch
wird das rechnerische Herz-Kreislaufrisiko
deutlich erniedrigt. Diese Funde legen die Vermutung nahe, dass
die Ernährung im frühesten Kindesalter bereits die Weichen
für den Fettstoffwechsel im Erwachsenenalter stellt.
STUDY SUGGESTS BREASTFEEDING REDUCES CARDIOVASCULAR RISK LATER
IN LIFE
Lancet
2004; 363: 1571-78; 1642-45
Breastfeeding in infancy is likely to reduce the risk of atherosclerosis-and
therefore cardiovascular disease-in adult life, suggest authors
of a UK study in this week's issue of THE LANCET.
There
are known to be many benefits from breastfeeding, although several
previous studies associating breastfeeding with reduced cardiovascular
disease in adulthood have been limited by methodological weaknesses,
such as retrospective study design. Atul Singhal from the Institute
of Child Health, London, UK, assessed prospectively whether preterm
infants who were breastfed were less likely to have markers for
atherosclerosis than preterm infants given formula milk.
The
investigators followed up 216 teenagers (aged 13-16 years) who
had been randomised to different milks in two trials for infant
nutrition (breastmilk verses preterm formula, and preterm formula
verses term formula) in the early 1980s. Among the measures used
at follow-up to assess adolescent lipoprotein profile (an indicator
of atherosclerosis risk) was the ratio of 'bad' to 'good' (LDL
to HDL) cholesterol, and concentrations of c-reactive protein
(CRP, higher concentrations are associated with the development
of atherosclerosis).
Those
adolescents who had been given breastmilk during infancy had a
14% lower ratio of LDL to HDL cholesterol and lower concentrations
of CRP than adolescents who had been given formula milk in infancy.
A greater proportion of human milk intake in infancy was associated
with lower ratios of LDL to HDL cholesterol.
Dr
Singhal comments: "The findings of our prospective study
suggest that infant nutrition permanently affects the lipoprotein
profile later in life, and specifically that breastmilk feeding
has a beneficial effect. Furthermore, we have shown a possible
benefit of breastmilk compared with formula feeding on later concentration
of CRP, a marker of the inflammatory process associated with atherosclerosis
and cardiovascular disease...Our findings suggest that breastmilk
feeding has a major beneficial effect onlong-term cardiovascular
health".
See
also Viewpoint: Early origins of cardiovascular disease: is there
a unifying hypothesis? (p 1642)
MRC
Press Office, T)+44(0)020 7637 6011; E) press.office@headoffice.mrc.ac.uk
Contact: Stephen Cox, Chief Press Officer, Great Ormond Street
Hospital for Children NHS Trust and the Institute of Child Health,
London, UK; T) +44 (0)20 7829 8671; E) CoxS@gosh.nhs.uk
Issue
15 May 2004
Embargoed 0001 h (London time) 14 May 2004. In North America the
embargo for Lancet press material is 6:30pm ET Thursday 13 May
2004.
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