Logo News Medizin 2000  
        >    Zurück

 | Home | Suche | Nutzung | Impressum| Kontakt |

Themen Websites  
im Info-Netzwerk
MEDIZIN 2000
 

15.11.2017

 

 

Quelle: New England Journal of Medicine

 

Als einzige Maßnahme zur Vermeidung des Hausstaubmilbenallergens ist milbenundurchlässige Bettwäsche bei erwachsenen Patienten mit allergisch bedingtem Asthma nicht geeignet, um die Atemnot zu bessern.

 

New England Journal of Medicine, Volume 349:225-236 July 17, 2003 Number 3


Control of Exposure to Mite Allergen and Allergen-Impermeable Bed Covers for Adults with Asthma


Ashley Woodcock, M.D., Louise Forster, Ph.D., Edward Matthews, B.A., Jeannett Martin, M.A., Louise Letley, R.G.N., Madge Vickers, Ph.D., John Britton, M.D., David Strachan, M.D., Peter Howarth, M.D., Daniel Altmann, D.Phil., Christopher Frost, Dip.Stat., Adnan Custovic, M.D., and The Medical Research Council General Practice Research Framework

Background The effectiveness of avoidance of house-dust-mite allergen (Dermatophagoides pteronyssinus 1 [Der p1]) in the management of asthma is uncertain.

Methods We conducted a double-blind, randomized, placebo-controlled study of allergen-impermeable bed covers involving 1122 adults with asthma. The primary outcomes were the mean morning peak expiratory flow rate over a four-week period during the run-in phase and at six months and the proportion of patients who discontinued inhaled corticosteroid therapy as part of a phased-reduction program during months 7 through 12. Der p1 was measured in mattress dust in a 10 percent random subsample of homes at entry and at 6 and 12 months.

Results The prevalence of sensitivity to dust-mite allergen was 65.4 percent in the group supplied with allergen-impermeable bed covers (active-intervention group) and 65.1 percent in the control group supplied with non-impermeable bed covers. The concentration of Der p1 in mattress dust was significantly lower in the active-intervention group at 6 months (geometric mean, 0.58 µg per gram vs. 1.71 µg per gram in the control group; P=0.01) but not at 12 months (1.05 µg per gram vs. 1.64 µg per gram; P=0.74). The mean morning peak expiratory flow rate improved significantly in both groups (from 410.7 to 419.1 liters per minute in the active-intervention group, P<0.001 for the change; and from 417.8 to 427.4 liters per minute in the control group, P<0.001 for the change).

After adjustment for base-line differences (by analysis of covariance), there was no significant difference between the groups in the peak expiratory flow rate at six months (difference in means, active-intervention group vs. control group, –1.6 liters per minute [95 percent confidence interval, –5.9 to 2.7] among all patients [P=0.46] and –1.5 liters per minute [95 percent confidence interval, –6.9 to 3.9] among mite-sensitive patients [P=0.59]).

There was no significant difference between the groups in the proportion in whom complete cessation of inhaled corticosteroid therapy was achieved (17.4 percent in the active-intervention group and 17.1 percent in the control group) or in the mean reduction in steroid dose, either among all patients or among mite-sensitive patients.

Conclusions   Allergen-impermeable covers, as a single intervention for the avoidance of exposure to dust-mite allergen, seem clinically ineffective in adults with asthma.


Source Information

From the South Manchester Academic Group, University of Manchester, North West Lung Centre, Wythenshawe Hospital, Manchester (A.W., A.C.); Medical Research Council General Practice Research Framework, London (L.F., E.M., J.M., L.L., M.V.); the Division of Epidemiology and Public Health, University of Nottingham, City Hospital, Nottingham (J.B.); the Department of Public Health Sciences, St. George's Hospital Medical School, London (D.S.); University Medicine, Southampton University General Hospital, Southampton (P.H.); and the Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London (D.A., C.F.) — all in the United Kingdom.

Address reprint requests to Dr. Woodcock at the North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, United Kingdom, or at ashley.a.woodcock@man.ac.uk.

Full Text

 

 

 

 

[an error occurred while processing this directive]

Mittelteil News werbefrei
WERBUNG INFO-NETZWERK MEDIZIN 2000










 





 






 



 






















 



 

 

 

 

zum Seitenanfang

 

Twitter auf Medizin 2000

 
            Werbung

Sie möchten die werbenden Texte in Ruhe durchlesen?
Kein Problem: die Bilderabfolge kann mit der Maus beliebig lange angehalten werden.

 

Natürlich heilen: Vitalstoffe -  Vitamine und Spurenelemente
   
Geo-Tours, Expeditionen,Erlebnisreisen
   
Analyse der Atemluft
   
Naturheilkunde-Kongresse 2014: Vitalstoffe - Vitamine und Spurenelemente
   
Orthomolekulare Medizin,Vitalstoffe: Vitamine und Spurenelemente
   
Sicherheit: Investieren in eine Privatinsel -  Bear Island, Nova Scotia
   
Das professionelle Bild: Rainer Erhard
   
Thymustherapie: Behandlung mit Thymusextrakten bei Abwehr- und Immunschwäche

 



Wichtige Themen-Websites im Info-Netzwerk Medizin 2000 
(13.12.2009)
 

| Anthroposophische Medizin | Abstammungsgutachten | ACE-Hemmer | Adipositas Therapie | AIDS/HIV | Allergie Therapie | alternative Krebs Therapie | Antibabypille |
| Arterienverkalkung | Arzt Beruf | Arthrose / Rheuma Therapie | Asthma Therapie | Audio Podcast | Augenheilkunde | Basalinsulin | Bienengift Allergie |
| Betablocker Therapie | Brustkrebs BehandlungCOPD Therapie | Deutsche Ärzte | Diabetes / Zuckerkrankheit | Diagnostica aktuell | DNA Vaterschaftstest |
| Erektile Dysfunktion| Endoprothese | Erkältungen | Evidence based Medicine | Frauenheilkunde | German Leading Hospitals | Gesundheitspolitik | Gräser Impf Tablette |
| Grippe News | Gynäkologie | Haarausfall | Hausarzt | Hausstaubmilben Allergie | Herzkrankheiten | Herzinfarkt Prophylaxe | Herzinfarkt Therapie |
 | Herzinsuffizienz Therapie | Herzinsuffizienz Diagnose Herzschrittmacher | Herzkrankheiten Heuschnupfen Therapie | Highlights Forschung |
 | Homöopathie | Homöopunktur | Hörgeräte | Hüftgelenk Endoprothese Hundehaar Allergie | Hunde Vermittlung | Hyperthermie Therapie  |
 | Hypertonie Therapie   | Impotenz Therapie | Impf-Schutz| Insektengift Allergie | Integrative Medizin | Kardiologie aktuell
| Humangenetik |   | Katzenhaar Allergie | Kniegelenks Endoprothese | Komplementärmedizin Onkologie | Krankenhäuser | Krebstherapie News |
 | Latex Allergie | Lebensmittel Allergie | Magenleiden | Medikamente News | Medizintechnik Medizin Recht | Mistel Therapie Krebs  |
 | Naturheilverfahren |  | Naturheilkunde | Natürlich heilen | Nervenkrankheiten | Nierenkrebs Therapie | Notfall Medizin | Onkologie News | online Hausarzt |
  | Orthomolekulare Medizin |Orthopädie | Osteoporose | Pollenallergie News | Pressearchiv | Presseerklärungen / Presseinfos | Reise |
 | Report Medizin | Rheuma | Sanotropika | Science Podcast  | Schmerztherapie | Schwerhörigkeit | Selbsthilfe Gruppen | Spezifische Immuntherapie SIT |
| Sport Medizin | Sublinguale spezifische Immuntherapie SLIT | Thymus Therapie | Tierhaarallergie | Tierschutz | Totalendoprothese TEP |
| Tumorvakzine News | unspezifische Immuntherapie | Video Podcast | Vaterschaftstest | Vitamine und Spurenelemente | Wespengift Allergie | ZNS Erkrankungen |
| Zuckerkrankheit | Info-Netzwerk Medizin 2000 | Nutzungsbedingungen | Stichwortsuche Info-Netzwerk Medizin 2000 | Impressum |
  

 

Werbung: 24 h Schlüsseldienst München

Copyright ©  LaHave Media Services Limited