Frauen, die über einen längeren Zeitraum eine Anti-Babypille
einnehmen machen sich große Sorgen über das Nebenwirkungsrisiko.
Jetzt zeigte eine große US-Studie, dass es keinen ursächlichen
Zusammenhang zwischen der Langzeiteinnahme der oralen Kontrazeptiva
und dem beobachteten Brustkrebsrisiko
BMJ 2002;325:8 ( 6 July )
NEJM Volume 346:2025-2032, June 27, 2002, Number 26
Oral Contraceptives and the Risk of Breast Cancer
Polly A. Marchbanks, Ph.D., Jill A. McDonald, Ph.D., Hoyt G. Wilson,
Ph.D., Suzanne G. Folger, Ph.D., Michele G. Mandel, B.A., Janet
R. Daling, Ph.D., Leslie Bernstein, Ph.D., Kathleen E. Malone,
Ph.D., Giske Ursin, M.D., Ph.D., Brian L. Strom, M.D., M.P.H.,
Sandra A. Norman, Ph.D., Phyllis A. Wingo, Ph.D., Ronald T. Burkman,
M.D., Jesse A. Berlin, Sc.D., Michael S. Simon, M.D., M.P.H.,
Robert Spirtas, Dr.P.H., and Linda K. Weiss, Ph.D.
Background It is uncertain whether the use of an oral contraceptive
increases the risk of breast cancer later in life, when the incidence
of breast cancer is increased. We conducted a population-based,
case–control study to determine the risk of breast cancer among
former and current users of oral contraceptives.
Methods We interviewed women who were 35 to 64 years old.
A total of 4575 women with breast cancer and 4682 controls were
interviewed. Conditional logistic regression was used to calculate
odds ratios as estimates of the relative risk (incidence-density
ratios) of breast cancer.
Results The relative risk was 1.0 (95 percent confidence
interval, 0.8 to 1.3) for women who were currently using oral
contraceptives and 0.9 (95 percent confidence interval, 0.8 to
1.0) for those who had previously used them. The relative risk
did not increase consistently with longer periods of
use or with higher doses of estrogen. The results were similar
among white and black women. Use of oral contraceptives by women
with a family history of breast cancer was not associated with
an increased risk of breast cancer, nor was the initiation of
oral-contraceptive use at a young age.
Conclusions Among women from 35 to 64 years of age, current
or former oral-contraceptive use was not
associated with a significantly increased risk of breast cancer.
From the Division of Reproductive Health, Centers for Disease
Control and Prevention, Atlanta (P.A.M., J.A.M., H.G.W., S.G.F.,
M.G.M.); the Fred Hutchinson Cancer Research
Center, Seattle (J.R.D., K.E.M.); the Department of Preventive
Medicine, Keck School of Medicine, University of Southern California,
Los Angeles (L.B., G.U.); the Center for
Clinical Epidemiology and Biostatistics and the Department of
Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia
(B.L.S., S.A.N.); and the Division of
Epidemiology, Karmanos Cancer Institute, Wayne State University,
Other authors were Phyllis A. Wingo, Ph.D., Department of Epidemiology
and Surveillance Research, American Cancer Society, Atlanta; Ronald
T. Burkman, M.D., Department of Obstetrics and Gynecology, Bay
State Medical Center, Springfield, Mass.; Jesse A. Berlin, Sc.D.,
Center for Clinical Epidemiology and Biostatistics and Department
of Biostatistics and Epidemiology, University of Pennsylvania,
Philadelphia; Michael S. Simon, M.D., M.P.H., Division of Hematology
and Oncology, Karmanos Cancer Institute, Wayne State University,
Detroit; and Robert Spirtas, Dr.P.H., Contraception and Reproductive
Health Branch, Center for Population Research, National Institute
of Child Health and Human Development, Bethesda, Md.
NEJM Volume 346:2025-2032
New study adds to evidence that taking oral contraception does
not increase risk
of breast cancer
Scott Gottlieb New York
A new study shows that older women who have used oral contraceptives
are no more likely to develop breast cancer than those who have
not, bolstering a growing body of evidence that no link exists.
But researchers cautioned that the new findings were limited to
the age group studied and that more research was warranted for
The study looked at nearly 9300 women aged 35 to 64. About half
of the women had developed breast cancer in the middle to late
1990s. The rest were healthy controls.
Interviews with the women showed that similar proportions of these
two groups had used contraceptives (79% of the group without cancer,
77% of the group with cancer). The relative risk was 1.0 (95%
confidence interval 0.8 to 1.3) for women who were currently using
oral contraceptives and 0.9 (0.8 to 1.0) for those who had previously
The risk did not increase with longer periods of use or with higher
doses of oestrogen, and the results were similar among white and
black women, among women with a family
history of breast cancer, and among those who had begun using
oral contraception at a young age (New England Journal and Medicine
The exception to these findings was among women aged 45 to 64
who were taking the pill to alleviate symptoms of menopause or
to reduce their risk of ovarian and endometrial
cancer and benign breast disease. The team found a slightly increased
risk of breast cancer among these women, but the number of women
studied in this group was too small to be significant.
The study focused on older women because of the higher incidence
of breast cancer in that age group. The findings essentially matched
the results of a major study in 1986 that also
showed no association between oral contraceptives and breast cancer.
"We conducted the study to resolve the longstanding concern,"
said Dr Robert Spirtas, chief of the National Institute of Child
Health and Human Development’s Contraception and
Reproductive Health branch and one of the authors of the study.
"Our study provides yet more scientific proof that there
isn’t an association."
In an accompanying editorial, Dr Kathy Helzlsouer and Dr Nancy
Davidson of Johns Hopkins University write that "for most
women, the benefits of avoiding pregnancy, with its
attendant health risks, clearly outweigh these side effects."
But they noted that oral contraceptives could also have other
adverse effects, including pulmonary embolism, strokes, liver
cancer, and, among smokers who are over age 35, heart problems.
Women who have a positive test result for the human papillomavirus
are also at increased risk of cervical cancer.
mehr Informationen (Originalquelle BMJ)