Der Allergie vorbeugen:
haben Kinder im ersten Lebensjahr Kontakt zu 2 oder mehr Hunden
so vermindert sich das spätere Allergierisiko ganz erheblich.
Exposure to Dogs and Cats in the First Year of Life and Risk
of Allergic Sensitization at 6 to 7 Years of Age
Dennis R. Ownby, MD; Christine Cole Johnson, PhD; Edward
L. Peterson, PhD
asthma is strongly associated with allergic sensitization. Studies
have suggested that animal exposure during infancy reduces subsequent
evaluate the relationship between dog and cat exposure in the
first year of life and allergic sensitization at 6 to 7 years
Setting, and Subjects Prospective birth cohort
study of healthy, full-term infants enrolled in a health maintenance
organization in suburban Detroit, Mich, who were born between
April 15, 1987, and August 31, 1989, and followed up yearly to
a mean age of 6.7 years. Of 835 children initially in the study
at birth, 474 (57%) completed follow-up evaluations at age 6 to
Outcome Measures Atopy, defined as any skin prick
test positivity to 6 common aeroallergens (dust mites [Dermatophagoides
farinae, D pteronyssinus], dog, cat, short ragweed [Ambrosia
artemisiifolia], and blue grass [Poa pratensis]); seroatopy,
defined as any positive allergen-specific IgE test result for
the same 6 allergens or for Alternaria species.
prevalence of any skin prick test positivity (atopy) at age 6
to 7 years was 33.6% with no dog or cat exposure in the first
year of life, 34.3% with exposure to 1 dog or cat, and 15.4% with
exposure to 2 or more dogs or cats (P = .005). The prevalence
of any positive allergen-specific IgE test result (seroatopy)
was 38.5% with no dog or cat exposure, 41.2% with exposure to
1 dog or cat, and 17.9% with exposure to 2 or more dogs or cats
(P = .003). After adjustment for cord serum IgE concentration,
sex, older siblings, parental smoking, parental asthma, bedroom
dust mite allergen levels at 2 years, and current dog and cat
ownership, exposure to 2 or more dogs or cats in the first year
of life was associated with a significantly lower risk of atopy
(adjusted odds ratio, 0.23; 95% confidence interval, 0.09-0.60)
and seroatopy (adjusted odds ratio, 0.33; 95% confidence interval,
to 2 or more dogs or cats in the first year of life may reduce
subsequent risk of allergic sensitization to multiple allergens
View Full Text
Author Affiliations: Section of Allergy and Immunology,
Department of Pediatrics, Medical College of Georgia, Augusta
(Dr Ownby); Department of Biostatistics and Research Epidemiology,
Henry Ford Health System, Detroit, Mich (Drs Johnson and Peterson);
National Institute of Environmental Health Sciences Center in
Molecular and Cellular Toxicology with Human Applications, Wayne
State University, Detroit (Drs Johnson and Peterson).
Corresponding Author and Reprints: Dennis R. Ownby, MD,
Section of Allergy and Immunology, Department of Pediatrics, BG-1019,
Medical College of Georgia, Augusta, GA 30912-3790 (e-mail: firstname.lastname@example.org).
Contributions: Study concept and design: Ownby, Johnson.
of data: Ownby, Johnson.
and interpretation of data: Ownby, Johnson, Peterson.
of the manuscript: Ownby, Johnson, Peterson.
revision of the manuscript for important intellectual content:
Ownby, Johnson, Peterson.
funding: Ownby, Johnson.
technical, or material support: Ownby, Johnson.
supervision: Ownby, Johnson.
This work was supported by grant AI 24156 from the National Institute
of Allergic and Infectious Diseases, by the Fund for Henry Ford
Hospital, and by grant PO3ES06639 from the National Institute
of Environmental Health Sciences.
Disclosure: Dr Ownby has received honoraria from AstraZeneca,
Genentech, GlaxoSmithKline, Schering, Merck, and Aventis.